F XI Deficiency Mutation Database©
Experimental Structures of FXI
  • All structural analysis of the mutations presented within this database uses the crystal structure of FXI (PDB code 2F83).
  • PDB Code Description Reference Resolution Domains
    2F83 Crystal Structure of FXI Papagrigoriou et al, 2006 2.87 Å All
  • There are several other crystal structures available for FXI domains which are listed below:
  • PDB Code Description Reference Resolution Domains
    1XX9 Crystal Structure of the FXIa Catalytic Domain in Complex with EcotinM84R Jin et al, 2005 2.2 Å SP
    1XXD Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin Jin et al, 2005 2.91 Å SP
    1XXF Crystal Structure of the FXIa Catalytic Domain in Complex with Ecotin Mutant (EcotinP) Jin et al, 2005 2.6 Å SP
    1ZHM Crystal Structure of the Catalytic Domain of the Coagulation Factor XIa in Complex with Benzamidine (S434A-T475A-K437 Mutant) Jin et al, 2005a 1.96 Å SP
    1ZHP Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Benzamidine (S434A-T475A-K505 Mutant) Jin et al, 2005a 2.7 Å SP
    1ZHR Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Benzamidine (S434A-T475A-C482S-K437A Mutant) Jin et al, 2005a 1.73 Å SP
    1ZJD Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II Navaneetham et al, 2005 2.6 Å SP
    1ZLR Factor XI catalytic domain complexed with 2-guanidino- 1-(4-( 4,4,5,5-tetramethyl-1,3, 2-dioxabo rolan -2-yl) phenyl) ethyl nicotinate 2.5 Å SP
    1ZMJ Crystal Structure of the Catalytic Domain of Factor XI in complex with 4-(guanidinomethyl)-pheny lboronic acid 2 Å SP
    1ZML Crystal Structure of the Catalytic Domain of Factor XI in complex with (R)-1-(4-(4- (hydroxymethyl)-1,3,2- dioxaborolan-2-yl) phenethyl) gu anidine 2.25 Å SP
    1ZMN Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with (R)-1-(4-(4-( hydroxymethyl)-1,3,2- dioxaborolan-2-yl)phenyl) guanidine 2.05 Å SP
    1ZOM Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with a peptidomime tic Inhibitor 2.25 Å SP
    1ZPB Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4- guanidino-1-(thiazole-2- carbonyl)- butylcarbamoyl]-2- methyl-propyl}-amide Deng et al., 2006 2.1 Å SP
    1ZPC Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-[2-(3- Chloro- phenyl)-2- hydroxy- acetylamino]- N-[ 4 -guanidino-1- (thiazole-2- carbonyl)-butyl ]-3-methyl-butyramide Deng et al., 2006 2.6 Å SP
    1ZPZ Factor XI catalytic domain complexed with N-((R) -1-(4-bromophenyl) ethyl)urea-Asn-Val-Arg-alpha - ketothiazole 2.5 Å SP
    1ZRK Factor XI complexed with 3-hydroxypropyl 3-(7-amidinonaphthalene-1-carboxamido)benzenesulfonate 2.3 Å SP
    1ZSJ Crystal Structure of the Catalytic Domain of Coagulation Factor XI in complex with N-(7- Carbamimidoyl-naphthalen-1-yl)- 3-hydroxy-2-methyl -benzamide 1.9 Å SP
    1ZSK Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 6-Carbamimidoyl-4-(3-hydroxy-2-methyl- benzoylamino)-nap hthalene-2- carboxylic acid methyl ester 1.9 Å SP
    1ZSL Factor XI complexed with a pyrimidinone inhibitor 2.05 Å SP
    1ZTJ Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-(5-Benzylamino-2- methylsulfanyl-6-oxo-6H- pyrimidin-1 -yl)-N- [4-guanidino-1- (thiazole-2-carbonyl )-butyl] -acetamide 2.05 Å SP
    1ZTK Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 2-(5-Amino-6-oxo-2-m-tolyl-6H-pyrimidin-1-yl)-N-[4-guani dino-1- (thiazole-2-carbonyl)-butyl]-acetamide 2.5 Å SP
    1ZTL Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with N-[4- Guanidino-1-( thiazole-2-carbonyl)- butyl]-2-{6-ox o- 5-[(quinolin-8 - ylmethyl)-amino]-2-m- tolyl-6H-pyrimidin-1-yl}-acetamide 2.6 Å SP
    2FDA Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand Jin et al, 2005a 2 Å SP
Homology Models of FXI
  • The models have been built using Insight II with Homology and Discover modules.
  • Feel free to download any of the models but please reference both the website and the paper (O'Connell et al 2005) if you use the models in any work.
  • Model Name Domain Template PDB
    AP1_HOM Ap1 1HKY.pdb
    AP2_HOM Ap2 1HKY.pdb
    AP3_HOM Ap3 1HKY.pdb
    AP4_HOM Ap4 1HKY.pdb
    SP_HOM SP 1A0L.pdb